Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in women with Overactive Bladder Syndrome: results of a randomized, controlled, crossover study

Pubblicato da il Mar 18, 2013 in | Commenti disabilitati su Solifenacin Succinate versus Percutaneous Tibial Nerve Stimulation in women with Overactive Bladder Syndrome: results of a randomized, controlled, crossover study

==inizio abstract==

Aims: This study compared the effectiveness of solifenacin succinate (SS) versus percutaneous tibial nerve stimulation (PTNS) in women with overactive bladder syndrome (OABS)
Methods: A randomized, controlled crossover study on 40 women with overactive bladder syndrome was performed.
Patients were randomized in two groups. In group A patients received solifenacin succinate and then percutaneous tibial nerve stimulation. In group B, patients underwent PTNS and then SS. Voiding diaries, quality of life surveys, patient’s perception of intensity of urgency questionnaire, were performed before and after each treatment. Global impression of improvement questionnaire was performed at the end of the study.
Results: A reduction in the number of daily micturitions, episodes of nocturia and urge incontinence were found both with SS and PTNS in all groups, but PTNS showed a greater effectiveness than SS.
There was an increase in voided volume in all groups both with SS and PTNS but patients treated with PTNS had a greater increase. PTNS showed greater effectiveness in patient’s perception of urgency and in the quality of life.
Conclusion: This study demonstrates the effectiveness of solifenacin succinate and percutaneous tibial nerve stimulation on women with overactive bladder symptoms. However, greater improvements were found with percutaneous tibial nerve stimulation.

==fine abstract==